2026
Chakravarty, A., Wang, L. N., Golden, R. P., Li, Z., Donovan, K. A., Afanzar, O., Zhang, Y., Fischer, E. S., Gray, N. S., & Yang, P. L. (2026). Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors. Nat. Commun., 17(1), 2594. doi.org/10.1038/s41467-026-69263-w
Parasar, B., Venkatesh, A. R., Perera, J., Sosnick, L., Moghadami, S., Seo, Y., Shi, J., Chan, L., Takenawa, S., Akiyama, T., Sianto, O., Uenaka, T., Hadjipanayis, A., Wernig, M., Gitler, A. D., & Tan, L. (2026). Whole-genome 3D architectural screen reveals modulators of brain DNA structure. bioRxiv [Preprint]. doi.org/10.64898/2026.04.15.718501
Parasar, B., Moghadami, S., Tan, L.. (2026). Lamin-ating the genome: quantitative gatekeeping of replication initiation. Trends Cell. Biol. doi: 10.1016/j.tcb.2026.08.010.
Feng, Z., Bearrood, T.E., Campbell, S.L., Kinsey, A.M., Matulionis, N., Chen, C.H., Seike, T., Leak, L., Tarhan, A.K., Dixon, S.J., Mochly-Rosen, D., Christofk, H.R., Chen, J.K. (2026). ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesis and fatty acid oxidation in colorectal cancer. bioRxiv [Preprint]. doi: 10.64898/2026.09.24.753323
Zhuang, Z., Togashi, R.K., Kearney, P.C., Pass, I., Swick, S.M., Zeng, F.Y., Bobkov, A.A., Fujimoto, L.M., Dutta, S., Zerva, A., Raig, N.D., Saha, D., Emami, A., Schwalm, M.P., Moon, B.K., Howard, S.T., Knapp, S., Hanke, T., Chung, T.D.Y., Chen, J.K. (2026). Small-Molecule Modulators of HIPK4 Activity and Proteostasis. J. Am. Chem. Soc. Advance online publication. https://doi.org/10.1021/jacs.6c10097
Rodell, R., Jain, R., Shenasa, H., Montes, M., Robalin, N., Prodic, S., Eyras, E., & Martinez, N.M. (2026). PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features. Cell Genom., Advance online publication. doi.org/10.1016/j.xgen.2026.101332
Zerva, A., Raig, N.D., Zhuang, Z., Kramer, A., Dopfer, J., Togashi, R.K., Schwalm, M.P., Elson, L., Frischkorn, J.M., Berger, B., Muller, S., Chen, J.K., Knapp, S., & Hanke, T. (2026). Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137. J. Med. Chem. doi.org/10.1021/acs.jmedchem.6c01320
Dado, R.S., Bordoloi, P., Xiong, Y., Liu, C.C., Brinkman, L.J., Moradifar, P., Pan, F., Tang, M.L., Brongersma, M., & Dionne, J. (2026). Metasurface-Enhanced Momentum-Resolved Circular Dichroism Spectroscopy. Nano Lett., 26(20), 6712-6718. https://:doi: 10.1021/acs.nanolett.6c01447
Back To Top2025
Chan, R., Cao, X., Ergun, S. L., Njomen, E., Lynch, S. R., Ritchie, C., Cravatt, B., & Li, L. (2025). Cysteine allostery and autoinhibition govern human STING oligomer functionality. Nat. Chem. Biol., 21, 1611-1620. doi.org/10.1038/s41589-025-01951-y
Carter, A. M., Woods, E. C., & Bogyo, M. (2025). Chemical strategies for targeting lipid pathways in bacterial pathogens. Curr. Opin. Chem. Biol., 86, 102596. doi.org/10.1016/j.cbpa.2025.102596
Bond, M. J., Golden, R. P., DiGiovanni, G., Howard, B., Sarott, R. C., Karim, B. A., Gourisankar, S., Alexe, G., Ross, K., Gray, N. S., & Stegmaier, K. (2025). Rewiring the fusion oncoprotein EWSR1::FLI1 in Ewing sarcoma with bivalent small molecules. J. Am. Chem. Soc., 147(49), 44739-44758. doi: 10.1021/jacs.5c05634
Ou, L., Setegne, M. T., Elliot, J., Shen, F., & Dassama, L. M. K. (2025). Protein-based degraders: From chemical biology tools to neo-therapeutics. Chem. Rev., 125(4), 2120–2183. doi.org/10.1021/acs.chemrev.4c00595
Moya-Garzon, M. D., Wang, M., Li, V. L., Lyu, X., Wei, W., Tung, A. S., Raun, S. H., Zhao, M., Coassolo, L., Islam, H., Oliveira, B., Dai, Y., Spaas, J., Delgado-Gonzalez, A., Donoso, K., Alvarez-Buylla, A., Franco-Montalban, F., Letian, A., Ward, C. P., Liu, L., … Long, J. Z. (2025). A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Cell, 188(1), 175–186.e20. doi.org/10.1016/j.cell.2024.10.032
Lopez-Pajares, V., Bhaduri, A., Zhao, Y., Gowrishankar, G., Donohue, L. K. H., Guo, M. G., Siprashvili, Z., Miao, W., Nguyen, D. T., Yang, X., Li, A. M., Tung, A. S., Shanderson, R. L., Winge, M. C. G., Meservey, L. M., Srinivasan, S., Meyers, R. M., Guerrero, A., Ji, A. L., Garcia, O. S., … Khavari, P. A. (2025). Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation. Cell Stem Cell, 32(5), 795–810.e10. doi.org/10.1016/j.stem.2025.02.017
Gentry, Z. O., McAteer, O. D., Hamad, J. L., Moran, J. A., Kim, J. T., Marsden, M. D., Zack, J. A., & Wender, P. A. (2025). Synthesis and preclinical evaluation of tigilanol tiglate analogs as latency-reversing agents for the eradication of HIV. Sci. Adv., 11(4), eads1911. doi.org/10.1126/sciadv.ads1911
Back To Top2024
Puzzo, F., Crossley, M. P., Goswami, A., Zhang, F., Pekrun, K., Garzon, J. L., Cimprich, K. A., & Kay, M. A. (2024). AAV-mediated genome editing is influenced by the formation of R-loops. Mol. Ther., 32(12), 4256–4271. doi.org/10.1016/j.ymthe.2024.09.035
Rodell, R., Robalin, N., & Martinez, N. M. (2024). Why U matters: Detection and functions of pseudouridine modifications in mRNAs. Trends Biochem. Sci., 49(1), 12–27. doi.org/10.1016/j.tibs.2023.10.008
Sarott, R. C., Gourisankar, S., Karim, B., Nettles, S., Yang, H., Dwyer, B. G., Simanauskaite, J. M., Tse, J., Abuzaid, H., Krokhotin, A., Zhang, T., Hinshaw, S. M., Green, M. R., Crabtree, G. R., & Gray, N. S. (2024). Relocalizing transcriptional kinases to activate apoptosis. Science, 386(6717), eadl5361. doi.org/10.1126/science.adl5361
Xiao, S., Li, V. L., Lyu, X., Chen, X., Wei, W., Abbasi, F., Knowles, J. W., Tung, A. S., Deng, S., Tiwari, G., Shi, X., Zheng, S., Farrell, L., Chen, Z. Z., Taylor, K. D., Guo, X., Goodarzi, M. O., Wood, A. C., Chen, Y. I., Lange, L. A., … Long, J. Z. (2024). Lac-Phe mediates the effects of metformin on food intake and body weight. Nat. Metabol., 6(4), 659–669. doi.org/10.1038/s42255-024-00999-9
Li, V. L., Xiao, S., Schlosser, P., Scherer, N., Wiggenhorn, A. L., Spaas, J., Tung, A. S., Karoly, E. D., Köttgen, A., & Long, J. Z. (2024). SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Nat. Commun., 15(1), 6895. doi.org/10.1038/s41467-024-51174-3
Elezaby, A., Lin, A. J., Vijayan, V., Pokhrel, S., Kraemer, B. R., Bechara, L. R. G., Larus, I., Sun, J., Baena, V., Syed, Z. A., Murphy, E., Glancy, B., Ostberg, N. P., Queliconi, B. B., Campos, J. C., Ferreira, J. C. B., Haileselassie, B., & Mochly-Rosen, D. (2024). Cardiac troponin I directly binds and inhibits mitochondrial ATP synthase with a noncanonical role in the post-ischemic heart. Nat. Cardiovasc. Res., 3(8), 987–1002. doi.org/10.1038/s44161-024-00512-1
Li, Z., Liu, H. Y., He, Z., Chakravarty, A., Golden, R. P., Jiang, Z., You, I., Yue, H., Donovan, K. A., Du, G., Che, J., Tse, J., Che, I., Lu, W., Fischer, E. S., Zhang, T., Gray, N. S., & Yang, P. L. (2024). Discovery of potent degraders of the dengue virus envelope protein. Adv. Sci., 11(40), e2405829. doi.org/10.1002/advs.202405829
Liu, H. Y., Li, Z., Reindl, T., He, Z., Qiu, X., Golden, R. P., Donovan, K. A., Bailey, A., Fischer, E. S., Zhang, T., Gray, N. S., & Yang, P. L. (2024). Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nat. Commun., 15(1), 5179. doi.org/10.1038/s41467-024-49161-9
Back To Top2023
Tan, L., Shi, J., Moghadami, S., Parasar, B., Wright, C. P., Seo, Y., Vallejo, K., Cobos, I., Duncan, L., Chen, R., & Deisseroth, K. (2023). Lifelong restructuring of 3D genome architecture in cerebellar granule cells. Science, 381(6662), 1112–1119. doi.org/10.1126/science.adh3253
Hsu, J., Fatuzzo, N., Weng, N., Michno, W., Dong, W., Kienle, M., Dai, Y., Pasca, A., Abu-Remaileh, M., Rasgon, N., Bigio, B., Nasca, C., & Khosla, C. (2023). Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. J. Biol. Chem., 299(2), 102848. doi.org/10.1016/j.jbc.2022.102848
Back To Top2022
Wender, P. A., Gentry, Z. O., Fanelli, D. J., Luu-Nguyen, Q. H., McAteer, O. D., & Njoo, E. (2022). Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues. Nat. Chem., 14(12), 1421–1426. doi.org/10.1038/s41557-022-01048-2
Chen, C. H., Kraemer, B. R., & Mochly-Rosen, D. (2022). ALDH2 variance in disease and populations. Dis. Model. Mech., 15(6), dmm049601. doi.org/10.1242/dmm.049601
Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S., Lyu, X., Zushin, P. H., Jansen, R. S., Michael, B., Loh, K. Y., Yang, A. C., Carl, C. S., Voldstedlund, C. T., Wei, W., Terrell, S. M., Moeller, B. C., Arthur, R. M., … Long, J. Z. (2022). An exercise-inducible metabolite that suppresses feeding and obesity. Nature, 606(7915), 785–790. doi.org/10.1038/s41586-022-04828-5
Frumkin, L. R., Lucas, M., Scribner, C. L., Ortega-Heinly, N., Rogers, J., Yin, G., Hallam, T. J., Yam, A., Bedard, K., Begley, R., Cohen, C. A., Badger, C. V., Abbasi, S. A., Dye, J. M., McMillan, B., Wallach, M., Bricker, T. L., Joshi, A., Boon, A. C. M., Pokhrel, S., … Mochly-Rosen, D. (2022). Egg-derived anti-SARS-CoV-2 immunoglobulin Y (IgY) with broad variant activity as intranasal prophylaxis against COVID-19. Front. Immunol., 13, 899617. doi.org/10.3389/fimmu.2022.899617
Brickner, J. R., Garzon, J. L., & Cimprich, K. A. (2022). Walking a tightrope: The complex balancing act of R-loops in genome stability. Mol. Cell, 82(12), 2267–2297. doi.org/10.1016/j.molcel.2022.04.014
Back To Top2021
Chen, C. H., Kraemer, B. R., Lee, L., & Mochly-Rosen, D. (2021). Annotation of 1350 common genetic variants of the 19 ALDH multigene family from global human Genome Aggregation Database (gnomAD). Biomolecules, 11(10), 1423. doi.org/10.3390/biom11101423
Pokhrel, S., Kraemer, B. R., Burkholz, S., & Mochly-Rosen, D. (2021). Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies. Sci. Rep., 11(1), 13120. doi.org/10.1038/s41598-021-92641-x
Pokhrel, S., Kraemer, B. R., Lee, L., Samardzic, K., & Mochly-Rosen, D. (2021). Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants’ spike protein-an in silico analysis. PloS One, 16(5), e0251426. doi.org/10.1371/journal.pone.0251426
Burkholz, S., Pokhrel, S., Kraemer, B. R., Mochly-Rosen, D., Carback, R. T., 3rd, Hodge, T., Harris, P., Ciotlos, S., Wang, L., Herst, C. V., & Rubsamen, R. (2021). Paired SARS-CoV-2 spike protein mutations observed during ongoing SARS-CoV-2 viral transfer from humans to minks and back to humans. Infect. Genet. Evol., 93, 104897. doi.org/10.1016/j.meegid.2021.104897
Back To Top