2025
Carter, A. M., Woods, E. C., & Bogyo, M. (2025). Chemical strategies for targeting lipid pathways in bacterial pathogens. Current opinion in chemical biology, 86, 102596. Advance online publication. https://doi.org/10.1016/j.cbpa.2025.102596
Bond, M. J., Golden, R. P., DiGiovanni, G., Howard, B., Sarott, R. C., Karim, B. A., Gourisankar, S., Alexe, G., Ross, K., Gray, N. S., & Stegmaier, K. (2025). Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules. bioRxiv : the preprint server for biology, 2025.03.14.643353. https://doi.org/10.1101/2025.03.14.643353
Ou, L., Setegne, M. T., Elliot, J., Shen, F., & Dassama, L. M. K. (2025). Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics. Chemical reviews, 125(4), 2120–2183. https://doi.org/10.1021/acs.chemrev.4c00595
Moya-Garzon, M. D., Wang, M., Li, V. L., Lyu, X., Wei, W., Tung, A. S., Raun, S. H., Zhao, M., Coassolo, L., Islam, H., Oliveira, B., Dai, Y., Spaas, J., Delgado-Gonzalez, A., Donoso, K., Alvarez-Buylla, A., Franco-Montalban, F., Letian, A., Ward, C. P., Liu, L., … Long, J. Z. (2025). A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Cell, 188(1), 175–186.e20. https://doi.org/10.1016/j.cell.2024.10.032
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Puzzo, F., Crossley, M. P., Goswami, A., Zhang, F., Pekrun, K., Garzon, J. L., Cimprich, K. A., & Kay, M. A. (2024). AAV-mediated genome editing is influenced by the formation of R-loops. Molecular therapy : the journal of the American Society of Gene Therapy, 32(12), 4256–4271. https://doi.org/10.1016/j.ymthe.2024.09.035
Rodell, R., Robalin, N., & Martinez, N. M. (2024). Why U matters: detection and functions of pseudouridine modifications in mRNAs. Trends in biochemical sciences, 49(1), 12–27. https://doi.org/10.1016/j.tibs.2023.10.008
Sarott, R. C., Gourisankar, S., Karim, B., Nettles, S., Yang, H., Dwyer, B. G., Simanauskaite, J. M., Tse, J., Abuzaid, H., Krokhotin, A., Zhang, T., Hinshaw, S. M., Green, M. R., Crabtree, G. R., & Gray, N. S. (2024). Relocalizing transcriptional kinases to activate apoptosis. Science (New York, N.Y.), 386(6717), eadl5361. https://doi.org/10.1126/science.adl5361
Xiao, S., Li, V. L., Lyu, X., Chen, X., Wei, W., Abbasi, F., Knowles, J. W., Tung, A. S., Deng, S., Tiwari, G., Shi, X., Zheng, S., Farrell, L., Chen, Z. Z., Taylor, K. D., Guo, X., Goodarzi, M. O., Wood, A. C., Chen, Y. I., Lange, L. A., … Long, J. Z. (2024). Lac-Phe mediates the effects of metformin on food intake and body weight. Nature metabolism, 6(4), 659–669. https://doi.org/10.1038/s42255-024-00999-9
Li, V. L., Xiao, S., Schlosser, P., Scherer, N., Wiggenhorn, A. L., Spaas, J., Tung, A. S., Karoly, E. D., Köttgen, A., & Long, J. Z. (2024). SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Nature communications, 15(1), 6895. https://doi.org/10.1038/s41467-024-51174-3
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Tan, L., Shi, J., Moghadami, S., Parasar, B., Wright, C. P., Seo, Y., Vallejo, K., Cobos, I., Duncan, L., Chen, R., & Deisseroth, K. (2023). Lifelong restructuring of 3D genome architecture in cerebellar granule cells. Science (New York, N.Y.), 381(6662), 1112–1119. https://doi.org/10.1126/science.adh3253
Hsu, J., Fatuzzo, N., Weng, N., Michno, W., Dong, W., Kienle, M., Dai, Y., Pasca, A., Abu-Remaileh, M., Rasgon, N., Bigio, B., Nasca, C., & Khosla, C. (2023). Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. The Journal of biological chemistry, 299(2), 102848. https://doi.org/10.1016/j.jbc.2022.102848
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Wender, P. A., Gentry, Z. O., Fanelli, D. J., Luu-Nguyen, Q. H., McAteer, O. D., & Njoo, E. (2022). Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues. Nature chemistry, 14(12), 1421–1426. https://doi.org/10.1038/s41557-022-01048-2
Chen, C. H., Kraemer, B. R., & Mochly-Rosen, D. (2022). ALDH2 variance in disease and populations. Disease models & mechanisms, 15(6), dmm049601. https://doi.org/10.1242/dmm.049601
Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S., Lyu, X., Zushin, P. H., Jansen, R. S., Michael, B., Loh, K. Y., Yang, A. C., Carl, C. S., Voldstedlund, C. T., Wei, W., Terrell, S. M., Moeller, B. C., Arthur, R. M., … Long, J. Z. (2022). An exercise-inducible metabolite that suppresses feeding and obesity. Nature, 606(7915), 785–790. https://doi.org/10.1038/s41586-022-04828-5
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